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Marlene Hernandez

Pearls on Benign Prostatic Hyperplasia

✨ Benign Prostatic Hyperplasia (BPH) is a condition that can affect quality of life, but there are treatment options to help manage symptoms. ⁠

✨ BPH is a non-cancerous enlargement of the prostate, often affecting men as they age. It’s driven by increased dihydrotestosterone (DHT) in the prostate, which promotes cellular growth and hyperplasia. This can block urine flow, causing lower urinary tract symptoms (LUTS) such as urgency, frequency, nocturia, and incomplete emptying.⁠

✨ There are many drugs that can worsen BPH. Check out the post for a fun mnemonic to help you learn the drugs.⁠

✨ Alpha-1 adrenergic antagonists relax bladder smooth muscle to reduce obstruction. Uroselective agents like tamsulosin, alfuzosin, and silodosin target alpha-1A receptors in the prostate, minimizing side effects like dizziness and orthostasis. However, they can increase the risk of Intraoperative Floppy Iris Syndrome during cataract surgery. Silodosin may cause sexual side effects, while alfuzosin can cause QT prolongation.⁠

✨ 5 alpha-reductase inhibitors shrink the prostate by inhibiting the conversion of testosterone to DHT. Finasteride targets type II alpha-reductase, while dutasteride inhibits both types. Dutasteride may require 6 months or more for maximum effect.⁠

✨ PDE-5 inhibitors promote smooth muscle relaxation in the prostate and bladder. BPH and erectile dysfunction (ED) often occur together. Caution is needed when using tadalafil with alpha-blockers due to the risk of hypotension, and is also contraindicated in patients taking nitrates.⁠

✨ By targeting the mechanisms driving prostate growth and urinary symptoms, we can help “clear the way” for better patient outcomes and “ease the flow” of their quality of life.⁠

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Pearls on Antidepressants

🤓Tips on selecting antidepressants⁠

💊 Selecting the right antidepressant can be overwhelming, but focusing on key patient characteristics helps make this process clearer. It is important to ensure you collect a thorough patient history to assess what treatments may or may not have worked for them.⁠

✨ It is important to consider pre-existing conditions a patient has before initiating an antidepressant. For example, if the patient has an increased risk for QT prolongation, it would be important to avoid antidepressants that can prolong the QTc such as citalopram, escitalopram, and tricyclic antidepressants (TCAs). Always evaluate for potential drug interactions and patient-specific risks, like fall concerns in elderly patients or adherence challenges in younger ones.⁠

✨ For treatment-resistant depression, options like augmentation (lithium, buspirone, atypical antipsychotics) or combining antidepressants with different mechanisms may be beneficial.⁠

💡 Use these pearls to guide your recommendations and provide personalized care for every patient.⁠

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Acid-Base Abnormalities

💊 Understanding acid-base abnormalities is crucial for diagnosing and managing various medical conditions. Let’s dive deeper into the specifics to strengthen your knowledge.⁠

✨ pH refers to how acidic or basic a solution is. If the solution becomes more acidic, the concentration of protons increases, and the pH decreases. The opposite occurs in a more basic solution: the concentration of protons decreases and the pH rises. A pH below 7.35 indicates acidosis, while a pH above 7.45 signifies alkalosis. These conditions are further classified as metabolic or respiratory based on the underlying cause (e.g., HCO3 or pCO2 changes).⁠

✨ The acid-base status of a patient can be determined using an arterial blood gas (ABG), consisting of pH, pCO2, pO2, HCO3, and O2 Sat. In the body, the kidneys help to maintain a neutral pH by controlling bicarbonate (HCO3) reabsorption and elimination. Bicarbonate therefore acts as a buffer as well as a base. The lungs also aid in maintaining a neutral pH in the body via the control of carbonic acid (directly proportional to the partial pressure of carbon dioxide: pCO2). Carbon dioxide also acts as a buffer as well as an acid. When we have variations in these levels, acid-base disturbances occur. ⁠

✨ Calculating the anion gap in metabolic acidosis can help pinpoint the cause. Remember the mnemonic MUDPILES for high anion gap acidosis. An anion gap is considered high if it is greater than 12 mEq/L. ⁠

✨ Recognizing these patterns and their compensatory responses is key to interpreting ABGs effectively. Keep practicing to master acid-base abnormalities! ⁠

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Insulin Dosing Calculations

💉Understanding insulin calculations is essential for the NAPLEX and for providing safe, effective patient care. Mastering these concepts will help you appropriately dose patients’ insulin in outpatient, inpatient, and emergent settings.

✨The Rule of 500 is used to estimate the insulin-to-carbohydrate ratio (ICR), which guides how much insulin a patient requires to manage carbohydrate intake during meals. This calculation is vital for individuals with diabetes, as it helps balance carbohydrate consumption and insulin dosing to prevent postprandial hyperglycemia.

✨The Rule of 1800 is used to determine the insulin sensitivity factor (ISF), which estimates how much one unit of rapid-acting insulin will lower a patient’s blood glucose. It provides a practical way to individualize insulin dosing based on patient-specific needs and ensures that high blood glucose levels can be managed safely without risking hypoglycemia. The Rule of 1800 is a key tool for improving glycemic control, especially in patients with variable blood glucose patterns, or those transitioning to insulin therapy.

✨Continuous infusion insulin is critical in the management of diabetic ketoacidosis (DKA). Continuous infusion provides a steady delivery of insulin. This is essential for suppressing ketogenesis, lowering blood glucose levels gradually, and correcting the metabolic abnormalities seen in DKA. This method allows for precise control of insulin administration, with the aim to prevent hypoglycemia or rapid shifts in osmolality. It requires close monitoring and adjustments based on the patient’s clinical response.

✨Insulin dosing can be complex but is manageable with the right tools. Focus on these foundational rules to ensure confidence in practice and patient safety. Happy learning!

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Antibiotic Considerations in Pediatrics

💊 Antibiotic choices in pediatrics require special care. Here are some considerations to keep in mind in this patient population.⁠

✨ Ceftriaxone and sulfamethoxazole/trimethoprim (Bactrim) can increase a patient’s risk for developing kernicterus. Kernicterus occurs when high levels of unconjugated bilirubin in a newborn’s blood cross the blood-brain barrier, depositing in brain tissues, thus causing neurotoxicity. This bilirubin buildup can lead to permanent neurological damage, which can manifest as movement disorders, hearing loss, and cognitive impairment.⁠

✨ Doxycycline and tigecycline can cause tooth staining in children by binding to calcium ions in developing teeth, leading to yellow-gray or brown discoloration. This happens during tooth mineralization, as the drugs incorporate into dentin and enamel, potentially causing permanent staining if given during key developmental periods, typically up to age 8.⁠

✨ Nitrofurantoin in pediatric patients under one-year-old for febrile urinary tract infections (UTIs) should be avoided as it doesn’t reach adequate concentrations in the kidneys to effectively treat upper urinary tract infections. It is difficult to distinguish cystitis from pyelonephritis in this population, thus other antibiotics are preferred to ensure appropriate treatment.⁠

✨ Fluoroquinolones can be used safely in pediatric patients when necessary, and risks and benefits should be carefully considered. Although tendon rupture is rare and occurs at similar rates in both children and adults, it’s important to recognize that the risk of arthrotoxicity is greater in pediatrics. Nevertheless, research indicates that these medications do not negatively impact growth in children.⁠


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Top 5 Mnemonics for NAPLEX

It’s NAPLEX season. Yup. The ONE test that every single pharmacy student has to pass to practice. 🙈⁠

🌟 The goal of the NAPLEX exam is to ensure you have the knowledge, judgment, and skills necessary to practice pharmacy at entry-level competency (AKA make sure you can practice pharmacy without killing someone). ⁠

🌟 It can be easy to get overwhelmed reviewing 4 years of pharmacy school into a couple of weeks. So what should you focus on? Start with the basics of drug therapy. You are more likely to get asked about a rare (but potentially fatal) side effect than you are to get asked about the 3rd line therapy with refractory hypertension or antibiotic choices for multidrug-resistant bacteria. Prioritize your studying accordingly. ⁠

⁠YOU GOT THISS!!

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Methotrexate

Hi! Meet ‘Mezzo’ (aka methotrexate). He is used to treat aches from various cancers and RA. He is widely popular being one of the top 200 drugs used in the United States but don’t let him fool you, he can pack quite a punch. ⁠

☝🏻 You need him at higher doses if you’re treating cancer but low doses can be used in severe cases of rheumatoid arthritis. ⁠

‼️ A lot of collateral damage (toxic side effects) can occur when he is around such as bone marrow suppression and liver damage can be found. ⁠

🌟 Last but not least, make sure to educate your patients completely about the appropriate dosing schedule of once-weekly. ⁠

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Hepatoxic Drugs

👊🏻 Drug-induced liver injury 🥊⁠

💊 There are SO many medications that can cause liver injury through various mechanisms. However, some key medications have black box warnings for liver toxicity and are more well-known for their risk. These are the ones that you should know for exams! 🗒️⁠

🔺 Hepatoxic drugs are usually well tolerated unless high doses are administered. In most cases, the primary treatment is to STOP the drug, especially when liver enzymes (AST and ALT) rise 3 times above their upper limit of normal.⁠

🧠 Some other helpful memory tips:⁠
-Acetaminophen’s brand name is Tylenol which looks similar to ‘Tired Liver’. ⁠
-Nefazodone and Nevirapine are never used anymore due to their severe liver toxicity so think never-zodone and never-apine. ⁠
-KEToconazole can KILL your liver⁠

🤔Some of them are a stretch but if you’re willing to try them out and they help you retain the information then that’s a win in my books. ✌🏻⁠


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 Total Parenteral Nutrition (TPN)

“If the gut works, use it!” but when it doesn’t…⁠

✨ Check out this post to learn more!⁠

💉 Total parenteral nutrition (TPN), also known as parenteral nutrition (PN) is a form of nutritional support given completely via the bloodstream, intravenously with an IV pump. ⁠

🍞 TPN administers proteins, carbohydrates, fats, vitamins, and minerals.⁠

 

 

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ACE inhibitors vs. ARBs.

                                                               What’s the difference?⁠

💊Angiotensin converting enzymes (ACE) inhibitors and angiotensin receptor blockers (ARBs) are antihypertensive medications used to treat high blood pressure and other comorbid conditions.⁠

💊While the enzyme inhibitors work by reducing the level of angiotensin II in the body, the receptor blockers inhibit the function of angiotensin II by directly blocking the specific receptor. ⁠

⭐️Key Takeaways⭐️⁠

-ACE inhibitors and ARBs have similar benefits, and both work equally well in the body though ARBs are thought to have less side effects. ⁠
-ACE inhibitors and ARBs are both considered first line for the treatment of hypertension. ⁠
-ACE inhibitors remain first line for HFrEF with ARBs as an alternative. ⁠
-For those who cannot tolerate an ACE inhibitor, ARBs are reasonable substitutes (ex: dry cough)⁠
-It is NOT recommended to treat hypertension patients with both ACE inhibitor and ARB as it can increase adverse effects. ⁠

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Inhaled Corticosteroid Combinations

🧠Memory tips for inhaled corticosteroid combinations!⁠

🌬️Inhaled corticosteroids are first-line options for treating patients with asthma. But many of these inhalers are brand-name only and some come in combination with long-acting beta 2 agonists or inhaled anticholinergics. ⁠

🫁Inhaled corticosteroids work by reducing inflammation and swelling in the airways. Reducing inflammation makes it easier to breathe, which minimizes asthma attacks. But these medications have to be taken daily, and it may take several weeks before they’re fully effective.⁠

🧠Some of these brands are often used on exams and it is helpful to know what their combinations are: ⁠

TIP – we would never put two corticosteroids together so for example if the question asks about Symbicort – the answer should be ✅️budesonide with formoterol (ICS + LABA) NOT ❌️budesonide with fluticasone (ICS + ICS). ⁠


⁠👉🏻Quiz yourself on how well you know the combinations and some of my memory tips on remembering them!

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Sertraline

😳 Since one of sertraline’s common side effect is diarrhea 💩, I called this piece ‘Squirtraline’. 💦 🤣⁠

💊 Sertraline belongs to the class selective serotonin reuptake inhibitors. SSRIs are like the traffic controllers of your brain’s serotonin levels. They help ensure that serotonin sticks around longer, improving symptoms of depression and anxiety. ⁠

🧠TIP: Serotonin is your ‘feel-good’ neurotransmitter. It is responsible for regulating mood, emotions, and even appetite. Sertraline’s role is to increase the amount of serotonin available in the brain by inhibiting its reuptake. Notice how SERtraline looks similar to SERotonin. ⁠

🌟Common side effects to know: ⁠

-Nausea/diarrhea⁠
-Headache⁠
-Changes in sleep pattern⁠
-Decreased libido and erectile dysfunction⁠

👉🏻Other than sexual side effects, symptoms often improve or resolve with time. ⁠

🗒️ Note: Sertraline is the most likely of the SSRIs to cause diarrhea. Research shows it may occur in up to 20% of people. Don’t fret – educate your patients that it will usually get better within a few weeks and to use antidiarrheal medications (ex: loperamide) in the short term. ⁠

💊 Starting doses: 12.5-25 mg daily and may increase to 25-50 mg increments⁠

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Amphotericin

If drugs came to life – Meet Ampho-terrible the fungal foe that packs a punch! 🥊 ⁠

🍄Amphotericin B is an antifungal medication that’s used to treat serious and life-threatening systemic fungal infections. But remember, with great power comes… well, some side effects! 😅⁠

✨The two main side effects to watch out for are nephrotoxicity and infusion-related reactions such as chills and fevers (often referred to as ‘shake and bake’). Because of its large side effect profile, it is often referred to as Ampho-TERRIBLE. ⁠

✨Some key things to keep in mind:⁠

-Liposomal amphotericin B (AmBisome) is a lipid formulation that a significantly improved toxicity profile compared to amphotericin B deoxycholate. ⁠

-Fevers, chills, and rigors are minimized by providing pre-medication with acetaminophen, diphenhydramine, and/or hydrocortisone 30–60 minutes prior to amphotericin B infusion.⁠

-The incidence and severity of nephrotoxicity can be reduced by providing 500–1000 mL bolus of normal saline before and after amphotericin B infusion.⁠

-Because it precipitates in normal saline, it must be given in a solution with 5% dextrose in water.⁠

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Atazanavir

⌛️ Time to get HIV Protease Outta Here with Atazanavir! 🦠💊 ⁠

🌟 Let’s talk about Atazanavir’s nickname, Bananavir. 🍌⁠

🌟 Atazanavir is used with other antiretroviral medications to treat human immunodeficiency virus (HIV). 🦠💊 It belongs to a class of drugs known as protease inhibitors. ⁠

🌟 One of the most common side effects with atazanavir is hyperbilirubinemia (35-49% of adults) causing yellow discoloration of the eyes and skin (jaundice) hence why this drug is often nicknamed BANANAVIR! 🍌Other common side effects include rash, nausea, headache, cough, fever, and hypercholesterolemia. ⁠

🌟 Key Points to Know For Exams⁠

-It is marketed under the brand name Reyataz⁠

-It works to inhibit HIV protease from breaking up large viral proteins into new mature HIV particles⁠

-It comes as a capsule and as a powder to be taken with food once a day to increase absorption⁠

-Hypersensitivity reaction can occur (Stevens-Johnson syndrome, toxic skin eruptions)⁠

-Beware of drug interactions as atazanavir is metabolized via CYP3A4 and it requires an acid gastric environment for optimal absorption (PPIs are contraindicated with use)⁠

-Atazanavir is often given with ritonavir to help boost levels of atazanavir concentrations⁠

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ototoxic drugs⁠

Ototoxic Drugs⁠

ototoxic drugs⁠

Hear me out as we discuss ototoxic drugs⁠

👂 Ototoxicity is a medication side effect involving damage to your inner ear. It can cause symptoms like ringing in your ears (tinnitus), hearing loss and balance problems.⁠

🌟 The risk for ototoxicity depends on the type of medication (common in some medications than others), the dose and duration of the medication, if you’re taking a combination of ototoxic drugs, and genetics. ⁠

🛑 The treatment is to stop the offending ototoxic agent. This often helps reverse the symptoms, although some ear damage may be permanent. ⁠

🌟 The most common drugs associated with ototoxicity includes aminoglycosides, chemotherapy such as cisplatin, loop diuretics, and salicylates. Check out today’s post to learn a fun mnemonic on other drugs that can cause ototoxicity. ⁠
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