👉🏻 Drugs that are inducers increase CYP450 enzyme activity by increasing enzyme synthesis. ⁠ ⁠ 👉🏻 A drug also may be metabolized by the same CYP450 enzyme that it induces. Carbamazepine (Tegretol), a potent enzyme inducer, must be initiated at a low dose and then increased at weekly intervals as its half-life gradually decreases over time.⁠