CYP450 Enzymes, Major Inducers of
👉🏻 Drugs that are inducers increase CYP450 enzyme activity by increasing enzyme synthesis.
👉🏻 A drug also may be metabolized by the same CYP450 enzyme that it induces. Carbamazepine (Tegretol), a potent enzyme inducer, must be initiated at a low dose and then increased at weekly intervals as its half-life gradually decreases over time.
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